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Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial | Nature Medicine

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SURPASSEARLY evaluated starting tirzepatide early in type 2 diabetes vs. conventional step-therapy. In adults with early T2D on metformin, tirzepatide produced larger 2year reductions in HbA1c, weight, and waist circumference than intensified

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